Sazetidine A dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1609
• Prices: $189.00
• Sizes: 10 mg
• Cas Number: 1197329-42-2
• Chemical Name: 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-oldihydrochloride
• Formula: C15H20N2O2.2HCl
• Molecular Weight: 333.25
• Purity: >98 %
• Description: Subtype-selective α 4 β 2 nicotinic acetylcholine receptor ligand (K i values are 0.26 and 54 nM at α 4 β 2 and α 3 β 4 receptors respectively). May act as a silent desensitizer or as an agonist, depending on subunit stoichiometry (EC 50 = 1.1 nM for nAChR-stimulated dopamine release). Exhibits analgesic activity in vivo and significantly reduces nicotine self-administration in an experimental rat model.

Product References

Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic - Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic

Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ. Mol Pharmacol. 2006 Oct;70(4):1454-60. Epub 2006 Jul 20.

Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug. - Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.

Cucchiaro G, Xiao Y, Gonzalez-Sulser A, Kellar KJ. Anesthesiology. 2008 Sep;109(3):512-9.

Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and - Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and

Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, Hampton D, Petro A, Rose JE, Brown ML, Paige MA, McDowell BE, Kellar KJ. J Pharmacol Exp Ther. 2010 Mar;332(3):933-9.