SB 202190

Name SB 202190
Supplier Tocris Bioscience
Catalog 1371
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 152121-30-7
Chemical Name 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Formula C20H14N3OF
Molecular Weight 331.35
Purity >99 %
Description A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC 50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Also available as part of the MAPK Inhibitor Tocriset™ .
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Product References

Characterization of the structure and function of a new mitogen-activated protein - Characterization of the structure and function of a new mitogen-activated protein

Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S, Han J. J Biol Chem. 1996 Jul 26;271(30):17920-6.

The activation state of p38 mitogen-activated protein kinase determines the - The activation state of p38 mitogen-activated protein kinase determines the

Frantz B, Klatt T, Pang M, Parsons J, Rolando A, Williams H, Tocci MJ, O'Keefe SJ, O'Neill EA. Biochemistry. 1998 Sep 29;37(39):13846-53.

Induction of apoptosis by SB202190 through inhibition of p38beta - Induction of apoptosis by SB202190 through inhibition of p38beta

Nemoto S, Xiang J, Huang S, Lin A. J Biol Chem. 1998 Jun 26;273(26):16415-20.

Specificity and mechanism of action of some commonly used protein kinase - Specificity and mechanism of action of some commonly used protein kinase

Davies SP, Reddy H, Caivano M, Cohen P. Biochem J. 2000 Oct 1;351(Pt 1):95-105.