SB 203580 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1202
• Prices: $259.00
• Sizes: 10 mg
• Cas Number: 869185-85-3
• Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridinehydrochloride
• Formula: C21H16FN3OS.HCl
• Molecular Weight: 413.89
• Purity: >98 %
• Description: Water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Product References

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated - SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated

Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. FEBS Lett. 1995 May 8;364(2):229-33.

Role for p38 mitogen-activated protein kinase in platelet aggregation caused by - Role for p38 mitogen-activated protein kinase in platelet aggregation caused by

Saklatvala J, Rawlinson L, Waller RJ, Sarsfield S, Lee JC, Morton LF, Barnes MJ, Farndale RW. J Biol Chem. 1996 Mar 22;271(12):6586-9.

Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 - Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580

Borsch-Haubold AG, Pasquet S, Watson SP. J Biol Chem. 1998 Oct 30;273(44):28766-72.

Specificity and mechanism of action of some commonly used protein kinase - Specificity and mechanism of action of some commonly used protein kinase

Davies SP, Reddy H, Caivano M, Cohen P. Biochem J. 2000 Oct 1;351(Pt 1):95-105.