SB 204070

• Supplier: Tocris Bioscience
• Catalog: 1402
• Prices: $205.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 148688-01-1
• Chemical Name: 8-Amino-7-chloro-2,3-dihydro-1,4-benzodioxan-5-carboxylicacid,1'-butyl-4'-piperidinylmethylester
• Formula: C19H27ClN2O4.HCl
• Molecular Weight: 419.34
• Purity: >98 %
• Description: Potent and selective 5-HT 4 receptor antagonist (pIC 50 = 10.1). Displays >5000-fold selectivity for 5-HT 4 over 5-HT 1A , 5-HT 1D , 5-HT 1E , 5-HT 2A , 5-HT 2C , and 5-HT 3 receptors. Exhibits anxiolytic activity upon systemic administration in vivo .

Product References

(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate - (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate

Gaster LM, Jennings AJ, Joiner GF, King FD, Mulholland KR, Rahman SK, Starr S, Wyman PA, Wardle KA, Ellis ES, et al.. J Med Chem. 1993 Dec 10;36(25):4121-3.

Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an - Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an

Bingham S, King BF, Rushant B, Smith MI, Gaster L, Sanger GJ. J Pharm Pharmacol. 1995 Mar;47(3):219-22.

An improved in vitro bioassay for the study of 5-HT(4) receptors in the human - An improved in vitro bioassay for the study of 5-HT(4) receptors in the human

Prins NH, Shankley NP, Welsh NJ, Briejer MR, Lefebvre RA, Akkermans LM, Schuurkes JA. Br J Pharmacol. 2000 Apr;129(8):1601-8.