SB 204741

• Supplier: Tocris Bioscience
• Catalog: 1373
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 152239-46-8
• Chemical Name: N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea
• Formula: C14H14N4OS
• Molecular Weight: 286.35
• Purity: >99 %
• Description: Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.

Product References

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) - The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B)

Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM. Br J Pharmacol. 1995 Jun;115(4):622-8.

N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity - N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity

Forbes IT, Jones GE, Murphy OE, Holland V, Baxter GS. J Med Chem. 1995 Mar 17;38(6):855-7.

Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated - Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated

Glusa E, Pertz HH. Br J Pharmacol. 2000 Jun;130(3):692-8.

Stimulating healthy tissue regeneration by targeting the 5-HT(2)B receptor in - Stimulating healthy tissue regeneration by targeting the 5-HT(2)B receptor in

Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffre F, Maroteaux L, Mann DA. Nat Med. 2011 Nov 27;17(12):1668-73.