SB 204990

• Supplier: Tocris Bioscience
• Catalog: 1372
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 154566-12-8
• Chemical Name: (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanaceticacid
• Formula: C18H22Cl2O5
• Molecular Weight: 389.27
• Purity: >98 %
• Description: ATP citrate lyase (ACLY) inhibitor. Prodrug of SB 201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. Orally active in vivo .

Product References

ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and - ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and

Gribble AD, Ife RJ, Shaw A, McNair D, Novelli CE, Bakewell S, Shah VP, Dolle RE, Groot PH, Pearce N, Yates J, Tew D, Boyd H, Ashman S, Eggleston DS, Haltiwanger RC, Okafo G. J Med Chem. 1998 Sep 10;41(19):3582-95.

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. - The role of ATP citrate-lyase in the metabolic regulation of plasma lipids.

Pearce NJ, Yates JW, Berkhout TA, Jackson B, Tew D, Boyd H, Camilleri P, Sweeney P, Gribble AD, Shaw A, Groot PH. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.