SB 205384

• Supplier: Tocris Bioscience
• Catalog: 4962
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 160296-13-9
• Chemical Name: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylicacid2-butynylester
• Formula: C17H18N2O3S
• Molecular Weight: 330.4
• Purity: >98 %
• Description: GABA A receptor modulator; slows current decay. Potentiates α 6, α 3 and α 5-subunit-containing receptors (EC 50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α 1 or α 2 subunits.

Product References

Effect of SB-205384 on the decay of GABA-activated chloride currents in granule - Effect of SB-205384 on the decay of GABA-activated chloride currents in granule

Meadows HJ, Harries MH, Thompson M, Benham CD. Br J Pharmacol. 1997 Aug;121(7):1334-8.

SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows - SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows

Meadows HJ, Kumar CS, Pritchett DB, Blackburn TP, Benham CD. Br J Pharmacol. 1998 Mar;123(6):1253-9.

Developmental change in GABAA receptor desensitization kinetics and its role in - Developmental change in GABAA receptor desensitization kinetics and its role in

Hutcheon B, Morley P, Poulter MO. J Physiol. 2000 Jan 1;522 Pt 1:3-17.

SB-205384 is a positive allosteric modulator of recombinant GABAA receptors - SB-205384 is a positive allosteric modulator of recombinant GABAA receptors

Heidelberg LS, Warren JW, Fisher JL. J Pharmacol Exp Ther. 2013 Oct;347(1):235-41.