SB 206553 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0921
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1197334-04-5
• Chemical Name: 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamidehydrochloride
• Formula: C17H16N4O.HCl
• Molecular Weight: 328.8
• Purity: >99 %
• Description: Potent and selective 5-HT 2B /5-HT 2C receptor antagonist (rat 5-HT 2B pA 2 = 8.89, human 5-HT 2C pK i = 7.92). Displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pK i < 6). Centrally active following oral administration in vivo .

Product References

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel - 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel

Forbes IT, Ham P, Booth DH, Martin RT, Thompson M, Baxter GS, Blackburn TP, Glen A, Kennett GA, Wood MD. J Med Chem. 1995 Jul 7;38(14):2524-30.

In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor - In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor

Kennett GA, Wood MD, Bright F, Cilia J, Piper DC, Gager T, Thomas D, Baxter GS, Forbes IT, Ham P, Blackburn TP. Br J Pharmacol. 1996 Feb;117(3):427-434.

5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo - 5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo

Porras G, Di Matteo V, Fracasso C, Lucas G, De Deurwaerdere P, Caccia S, Esposito E, Spampinato U. Neuropsychopharmacology. 2002 Mar;26(3):311-24.