SB 215505

• Supplier: Tocris Bioscience
• Catalog: 1661
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 162100-15-4
• Chemical Name: 6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide
• Formula: C19H16ClN3O
• Molecular Weight: 337.81
• Purity: >98 %
• Description: Potent 5-HT 2B/2C receptor antagonist (pK i values are 8.3, 7.66 and 6.77 for 5-HT 2B , 5-HT 2C and 5-HT 2A respectively). Increases wakefulness and motor activity in rats. Orally active.

Product References

Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B - Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B

Kennett GA, Trail B, Bright F. Neuropharmacology. 1998 Dec;37(12):1603-10.

Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. - Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist.

Reavill C, Kettle A, Holland V, Riley G, Blackburn TP. Br J Pharmacol. 1999 Feb;126(3):572-4.

Increased wakefulness, motor activity and decreased theta activity after blockade - Increased wakefulness, motor activity and decreased theta activity after blockade

Kantor S, Jakus R, Balogh B, Benko A, Bagdy G. Br J Pharmacol. 2004 Aug;142(8):1332-42. Epub 2004 Jul 20.