| Name | SB 216763 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1242 |
| Prices | $85.00, $175.00, $709.00 |
| Sizes | 1 mg, 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 280744-09-4 |
| Chemical Name | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Formula | C19H12Cl2N2O2 |
| Molecular Weight | 371.22 |
| Purity | >98 % |
| Description | Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC 50 = 34.3 nM for GSK-3 α ). Equally effective at inhibiting human GSK-3 α and GSK-3 β . Exhibits minimal activity against 24 other protein kinases (IC 50 >10 μ M). Stimulates glycogen synthesis in liver cells, and induces β -catenin-dependent gene transcription. Neuroprotective; also reduces pulmonary inflammation and fibrosis in a mouse model. Shown to maintain mouse embryonic stem cells in a pluripotent state. |
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