| Name | SB 218078 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1616 |
| Prices | $125.00, $269.00 |
| Sizes | 1 mg, 10 mg |
| Function Type | Inhibitor |
| Cas Number | 135897-06-2 |
| Chemical Name | 9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione |
| Formula | C24H15N3O3 |
| Molecular Weight | 393.39 |
| Purity | >98 % |
| Description | Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC 50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G 2 cell cycle arrest caused by γ -irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. |
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