SB 218795

• Supplier: Tocris Bioscience
• Catalog: 2560
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 174635-53-1
• Chemical Name: (R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methylesterbenzeneaceticacid
• Formula: C25H20N2O3
• Molecular Weight: 396.44
• Purity: >99 %
• Description: Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.

Product References

Discovery of a novel class of selective non-peptide antagonists for the human - Discovery of a novel class of selective non-peptide antagonists for the human

Giardina GA, Sarau HM, Farina C, Medhurst AD, Grugni M, Raveglia LF, Schmidt DB, Rigolio R, Luttmann M, Vecchietti V, Hay DW. J Med Chem. 1997 Jun 6;40(12):1794-807.

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use - In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use

Medhurst AD, Hay DW, Parsons AA, Martin LD, Griswold DE. Br J Pharmacol. 1997 Oct;122(3):469-76.