SB 221284

• Supplier: Tocris Bioscience
• Catalog: 1376
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 196965-14-7
• Chemical Name: 2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-1H-indole-1-carboxamide
• Formula: C16H14F3N3OS
• Molecular Weight: 353.36
• Purity: >99 %
• Description: Potent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .

Product References

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic - Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic

Bromidge SM, Dabbs S, Davies DT, Duckworth DM, Forbes IT, Ham P, Jones GE, King FD, Saunders DV, Starr S, Thewlis KM, Wyman PA, Blaney FE, Naylor CB, Bailey F, Blackburn TP, Holland V, Kennett GA, Riley GJ, Wood MD. J Med Chem. 1998 May 7;41(10):1598-612.

Evidence for accelerated desensitisation of 5-HT(2C) receptors following combined - Evidence for accelerated desensitisation of 5-HT(2C) receptors following combined

Bristow LJ, O'Connor D, Watts R, Duxon MS, Hutson PH. Neuropharmacology. 2000 Apr 27;39(7):1222-36.

Activation of mesolimbic dopamine function by phencyclidine is enhanced by - Activation of mesolimbic dopamine function by phencyclidine is enhanced by

Hutson PH, Barton CL, Jay M, Blurton P, Burkamp F, Clarkson R, Bristow LJ. Neuropharmacology. 2000 Sep;39(12):2318-28.