SB 222200

• Supplier: Tocris Bioscience
• Catalog: 1379
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 174635-69-9
• Chemical Name: 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
• Formula: C26H24N2O
• Molecular Weight: 380.48
• Purity: >98 %
• Description: Potent and selective non-peptide NK 3 receptor antagonist (K i values are 4.4, > 100,000 and 250 nM for human NK 3 , NK 1 and NK 2 receptors respectively). Antihypertensive in vivo . Brain penetrant.

Product References

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use - In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use

Medhurst AD, Hay DW, Parsons AA, Martin LD, Griswold DE. Br J Pharmacol. 1997 Oct;122(3):469-76.

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and - Nonpeptide tachykinin receptor antagonists. II. Pharmacological and

Sarau HM, Griswold DE, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Webb EF, Martin LD, Legos JJ, Whitmore RG, Barone FC, Medhurst AD, Luttmann MA, Giardina GA, Hay DW. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.

Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic - Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic

De Brito Gariepy H, Couture R. Br J Pharmacol. 2010 Dec;161(8):1868-84.