SB 224289 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4672
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 180084-26-8
• Chemical Name: 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidinehydrochloride
• Formula: C32H32N4O3.HCl
• Molecular Weight: 557.09
• Purity: >95 %
• Description: Selective 5-HT 1B receptor antagonist (pK i = 8.2). Displays > 60-fold selectivity over 5-HT 1D , 5-HT 1A , 5-HT 1E , 5-HT 1F , 5-HT 2A and 5-HT 2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo .

Product References

Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. - Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.

Hagan JJ, Slade PD, Gaster L, Jeffrey P, Hatcher JP, Middlemiss DN. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74.

The selective 5-HT1B receptor inverse agonist - The selective 5-HT1B receptor inverse agonist

Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD. J Med Chem. 1998 Apr 9;41(8):1218-35.

Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe - Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe

Roberts C, Belenguer A, Middlemiss DN, Routledge C. Eur J Pharmacol. 1998 Apr 10;346(2-3):175-80.

SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative - SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative

Selkirk JV, Scott C, Ho M, Burton MJ, Watson J, Gaster LM, Collin L, Jones BJ, Middlemiss DN, Price GW. Br J Pharmacol. 1998 Sep;125(1):202-8.