SB 225002

• Supplier: Tocris Bioscience
• Catalog: 1221
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 182498-32-4
• Chemical Name: N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea
• Formula: C13H10BrN3O4
• Molecular Weight: 352.14
• Purity: >99 %
• Description: Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.

Product References

Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits - Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits

White JR, Lee JM, Young PR, Hertzberg RP, Jurewicz AJ, Chaikin MA, Widdowson K, Foley JJ, Martin LD, Griswold DE, Sarau HM. J Biol Chem. 1998 Apr 24;273(17):10095-8.

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a - Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a

Lane BR, Lore K, Bock PJ, Andersson J, Coffey MJ, Strieter RM, Markovitz DM. J Virol. 2001 Sep;75(17):8195-202.

Characterization of the molecular interactions of interleukin-8 (CXCL8), growth - Characterization of the molecular interactions of interleukin-8 (CXCL8), growth

Catusse J, Liotard A, Loillier B, Pruneau D, Paquet JL. Biochem Pharmacol. 2003 Mar 1;65(5):813-21.