SB 228357

• Supplier: Tocris Bioscience
• Catalog: 2725
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 181629-93-6
• Chemical Name: N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
• Formula: C22H17F4N3O2
• Molecular Weight: 431.39
• Purity: >99 %
• Description: 5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .

Product References

Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. - Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist.

Reavill C, Kettle A, Holland V, Riley G, Blackburn TP. Br J Pharmacol. 1999 Feb;126(3):572-4.

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse - Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse

Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, Mulholland KR, Saunders DV, Wyman PA, Blaney FE, Clarke SE, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Trail B, Riley GJ, Wood MD. J Med Chem. 2000 Mar 23;43(6):1123-34.