SB 239063

• Supplier: Tocris Bioscience
• Catalog: 1375
• Prices: $265.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 193551-21-2
• Chemical Name: trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
• Formula: C20H21FN4O2
• Molecular Weight: 368.41
• Purity: >98 %
• Description: Potent and selective p38 MAP kinase inhibitor (IC 50 = 44 nM for p38 α ). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo .

Product References

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine - SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine

Underwood DC, Osborn RR, Kotzer CJ, Adams JL, Lee JC, Webb EF, Carpenter DC, Bochnowicz S, Thomas HC, Hay DW, Griswold DE. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8.

SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, - SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor,

Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, White RF, McVey MJ, Legos JJ, Erhardt JA, Nelson AH, Ohlstein EH, Hunter AJ, Ward K, Smith BR, Adams JL, Parsons AA. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21.

The selective p38 inhibitor SB-239063 protects primary neurons from mild to - The selective p38 inhibitor SB-239063 protects primary neurons from mild to

Legos JJ, McLaughlin B, Skaper SD, Strijbos PJ, Parsons AA, Aizenman E, Herin GA, Barone FC, Erhardt JA. Eur J Pharmacol. 2002 Jun 28;447(1):37-42.