SB 242084

• Supplier: Tocris Bioscience
• Catalog: 1962
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1215566-78-1
• Chemical Name: 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamidedihydrochloride
• Formula: C21H19ClN4O2.2HCl
• Molecular Weight: 467.78
• Purity: >99 %
• Description: 5-HT 2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT 2A and 5-HT 2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.

Product References

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline - 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline

Bromidge SM, Duckworth M, Forbes IT, Ham P, King FD, Thewlis KM, Blaney FE, Naylor CB, Blackburn TP, Kennett GA, Wood MD, Clarke SE. J Med Chem. 1997 Oct 24;40(22):3494-6.

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. - SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.

Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour - Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour

Dalton GL, Lee MD, Kennett GA, Dourish CT, Clifton PG. Psychopharmacology (Berl). 2006 Mar;185(1):45-57. Epub 2006 Feb 10.