SB 243213 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2901
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 200940-23-4
• Chemical Name: 2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamidedihydrochloride
• Formula: C22H19F3N4O2.2HCl
• Molecular Weight: 501.33
• Purity: >99 %
• Description: Selective 5-HT 2C inverse agonist (pK b = 9.8). Displays selectivity over other 5-HT 2 subtypes (pK i values are 6.8, 7.0 and 9.0 for 5-HT 2A , 5-HT 2B and 5-HT 2C respectively); also exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. Displays anxiolytic activity in rat models.

Product References

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse - Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse

Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, Mulholland KR, Saunders DV, Wyman PA, Blaney FE, Clarke SE, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Trail B, Riley GJ, Wood MD. J Med Chem. 2000 Mar 23;43(6):1123-34.

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic - SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic

Wood MD, Reavill C, Trail B, Wilson A, Stean T, Kennett GA, Lightowler S, Blackburn TP, Thomas D, Gager TL, Riley G, Holland V, Bromidge SM, Forbes IT, Middlemiss DN. Neuropharmacology. 2001 Aug;41(2):186-99.

Differential effects of - Differential effects of

Berg KA, Navailles S, Sanchez TA, Silva YM, Wood MD, Spampinato U, Clarke WP. J Pharmacol Exp Ther. 2006 Oct;319(1):260-8. Epub 2006 Jun 28.