SB 258585 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3527
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1216468-02-8
• Chemical Name: 4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamidehydrochloride
• Formula: C18H22IN3O3S.HCl
• Molecular Weight: 523.82
• Purity: >99 %
• Description: Potent and selective 5-HT 6 receptor antagonist (pK i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.

Product References

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- - 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon-

Bromidge SM, Brown AM, Clarke SE, Dodgson K, Gager T, Grassam HL, Jeffrey PM, Joiner GF, King FD, Middlemiss DN, Moss SF, Newman H, Riley G, Routledge C, Wyman P. J Med Chem. 1999 Jan 28;42(2):202-5.

Characterization of [(125)I]-SB-258585 binding to human recombinant and native - Characterization of [(125)I]-SB-258585 binding to human recombinant and native

Hirst WD, Minton JA, Bromidge SM, Moss SF, Latter AJ, Riley G, Routledge C, Middlemiss DN, Price GW. Br J Pharmacol. 2000 Aug;130(7):1597-605.

5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug - 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug

East SZ, Burnet PW, Leslie RA, Roberts JC, Harrison PJ. Synapse. 2002 Sep 1;45(3):191-9.