SB 258719 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1961
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1217674-10-6
• Chemical Name: 3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamidehydrochloride
• Formula: C18H30N2O2S.HCl
• Molecular Weight: 374.97
• Purity: >99 %
• Description: Selective 5-HT 7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

Product References

(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) - (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)

Forbes IT, Dabbs S, Duckworth DM, Jennings AJ, King FD, Lovell PJ, Brown AM, Collin L, Hagan JJ, Middlemiss DN, Riley GJ, Thomas DR, Upton N. J Med Chem. 1998 Feb 26;41(5):655-7.

Functional characterisation of the human cloned 5-HT7 receptor (long form); - Functional characterisation of the human cloned 5-HT7 receptor (long form);

Thomas DR, Gittins SA, Collin LL, Middlemiss DN, Riley G, Hagan J, Gloger I, Ellis CE, Forbes IT, Brown AM. Br J Pharmacol. 1998 Jul;124(6):1300-6.

The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. - The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor.

Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, McAllister G, Fone KC, Hutson PH. Neuropharmacology. 2003 Jun;44(8):1031-7.