SB 265610

Name SB 265610
Supplier Tocris Bioscience
Catalog 2726
Prices $95.00, $199.00, $825.00
Sizes 1 mg, 10 mg, 50 mg
Function Type Antagonist
Cas Number 211096-49-0
Chemical Name N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Formula C14H9BrN6O
Molecular Weight 357.16
Purity >98 %
Description Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
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Product References

Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed - Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed

Auten RL, Richardson RM, White JR, Mason SN, Vozzelli MA, Whorton MH. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.

Impaired healing of nitrogen mustard wounds in CXCR2 null mice. - Impaired healing of nitrogen mustard wounds in CXCR2 null mice.

Milatovic S, Nanney LB, Yu Y, White JR, Richmond A. Wound Repair Regen. 2003 May-Jun;11(3):213-9.