SB 269970 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4314
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 261901-57-9
• Chemical Name: (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidinehydrochloride
• Formula: C18H28N2O3S.HCl
• Molecular Weight: 388.95
• Purity: >98 %
• Description: Potent and selective 5-HT 7 receptor antagonist (pK i values are 8.9, 7.2 and 6.0 for 5-HT 7A , 5-HT 5A and 5-HT 1B and < 6.0 for 5-HT 1A , 5-HT 1D , 5-HT 1E , 5-HT 1F , 5-HT 2A , 5-HT 2B , 5-HT 2C , 5-HT 4 and 5-HT 6 receptors respectively). Brain penetrant in vivo .

Product References

Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. - Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.

Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smith MI, Upton N, Medhurst AD, Middlemiss DN, Riley GJ, Lovell PJ, Bromidge SM, Thomas DR. Br J Pharmacol. 2000 Jun;130(3):539-48.

A novel, potent, and selective 5-HT(7) antagonist: - A novel, potent, and selective 5-HT(7) antagonist:

Lovell PJ, Bromidge SM, Dabbs S, Duckworth DM, Forbes IT, Jennings AJ, King FD, Middlemiss DN, Rahman SK, Saunders DV, Collin LL, Hagan JJ, Riley GJ, Thomas DR. J Med Chem. 2000 Feb 10;43(3):342-5.

DR4004, a putative 5-HT(7) receptor antagonist, also has functional activity at - DR4004, a putative 5-HT(7) receptor antagonist, also has functional activity at

Kogan HA, Marsden CA, Fone KC. Eur J Pharmacol. 2002 Aug 2;449(1-2):105-11.