| Name | SB 297006 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4207 |
| Prices | $175.00, $709.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 58816-69-6 |
| Chemical Name | N-Benzoyl-4-nitroanilineethylester |
| Formula | C18H18N2O5 |
| Molecular Weight | 342.35 |
| Purity | >99 % |
| Description | Potent and selective CCR3 antagonist (IC 50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC 50 >27 μ M). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC 50 values are 80, 90 and 210 nM respectively). |
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Yoshimoto M, Hansch C. J Org Chem. 1976 Jun 25;41(13):2269-73.
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