SB 328437

• Supplier: Tocris Bioscience
• Catalog: 4213
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 247580-43-4
• Chemical Name: N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester
• Formula: C21H18N2O5
• Molecular Weight: 378.38
• Purity: >99 %
• Description: Potent and selective CCR3 antagonist (IC 50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD 4 , CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca 2+ mobilization (IC 50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

Product References

Identification of potent, selective non-peptide CC chemokine receptor-3 - Identification of potent, selective non-peptide CC chemokine receptor-3

White JR, Lee JM, Dede K, Imburgia CS, Jurewicz AJ, Chan G, Fornwald JA, Dhanak D, Christmann LT, Darcy MG, Widdowson KL, Foley JJ, Schmidt DB, Sarau HM. J Biol Chem. 2000 Nov 24;275(47):36626-31.

Selective suppression of Th2-mediated airway eosinophil infiltration by - Selective suppression of Th2-mediated airway eosinophil infiltration by

Mori A, Ogawa K, Someya K, Kunori Y, Nagakubo D, Yoshie O, Kitamura F, Hiroi T, Kaminuma O. Int Immunol. 2007 Aug;19(8):913-21.