SB 332235

• Supplier: Tocris Bioscience
• Catalog: 3650
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 276702-15-9
• Chemical Name: 6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide
• Formula: C13H10Cl3N3O4S
• Molecular Weight: 410.66
• Purity: >98 %
• Description: Potent CXCR2 antagonist (IC 50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro .

Product References

A selective orexin-1 receptor antagonist reduces food consumption in male and - A selective orexin-1 receptor antagonist reduces food consumption in male and

Haynes AC, Jackson B, Chapman H, Tadayyon M, Johns A, Porter RA, Arch JR. Regul Pept. 2000 Dec 22;96(1-2):45-51.

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) - Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1)

Duxon MS, Stretton J, Starr K, Jones DN, Holland V, Riley G, Jerman J, Brough S, Smart D, Johns A, Chan W, Porter RA, Upton N. Psychopharmacology (Berl). 2001 Jan 1;153(2):203-9.

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. - 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.

Porter RA, Chan WN, Coulton S, Johns A, Hadley MS, Widdowson K, Jerman JC, Brough SJ, Coldwell M, Smart D, Jewitt F, Jeffrey P, Austin N. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10.

SB-334867-A: the first selective orexin-1 receptor antagonist. - SB-334867-A: the first selective orexin-1 receptor antagonist.

Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA, Jerman JC. Br J Pharmacol. 2001 Mar;132(6):1179-82.