SB 366791

• Supplier: Tocris Bioscience
• Catalog: 1960
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 472981-92-3
• Chemical Name: 4'-Chloro-3-methoxycinnamanilide
• Formula: C16H14ClNO2
• Molecular Weight: 287.75
• Purity: >99 %
• Description: Potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .

Product References

Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, - Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol,

Fowler CJ, Jonsson KO, Andersson A, Juntunen J, Jarvinen T, Vandevoorde S, Lambert DM, Jerman JC, Smart D. Biochem Pharmacol. 2003 Sep 1;66(5):757-67.

Identification and characterisation of SB-366791, a potent and selective - Identification and characterisation of SB-366791, a potent and selective

Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Luis Hannan S, Lappin SC, Egerton J, Smith GD, Worby A, Howett L, Owen D, Nasir S, Davies CH, Thompson M, Wyman PA, Randall AD, Davis JB. Neuropharmacology. 2004 Jan;46(1):133-49.

Proton activation does not alter antagonist interaction with the - Proton activation does not alter antagonist interaction with the

Gavva NR, Tamir R, Klionsky L, Norman MH, Louis JC, Wild KD, Treanor JJ. Mol Pharmacol. 2005 Dec;68(6):1524-33. Epub 2005 Aug 31.