SB 415286

• Supplier: Tocris Bioscience
• Catalog: 1963
• Prices: $185.00, $759.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 264218-23-7
• Chemical Name: 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
• Formula: C16H10ClN3O5
• Molecular Weight: 359.73
• Purity: >99 %
• Description: Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 31 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Product References

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate - Selective small molecule inhibitors of glycogen synthase kinase-3 modulate

Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, Pearce NJ, Rausch OL, Murphy GJ, Carter PS, Roxbee Cox L, Mills D, Brown MJ, Haigh D, Ward RW, Smith DG, Murray KJ, Reith AD, Holder JC. Chem Biol. 2000 Oct;7(10):793-803.

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity - Selective small-molecule inhibitors of glycogen synthase kinase-3 activity

Cross DA, Culbert AA, Chalmers KA, Facci L, Skaper SD, Reith AD. J Neurochem. 2001 Apr;77(1):94-102.

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal - Regulation and function of glycogen synthase kinase-3 isoforms in neuronal

Liang MH, Chuang DM. J Biol Chem. 2007 Feb 9;282(6):3904-17. Epub 2006 Dec 5.