SB 452533

• Supplier: Tocris Bioscience
• Catalog: 1614
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 459429-39-1
• Chemical Name: N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea
• Formula: C18H22BrN3O
• Molecular Weight: 376.29
• Purity: >98 %
• Description: Potent TRPV1 antagonist against capsaicin (pK b = 7.7), noxious heat and acid-mediated (pIC 50 = 7.0) receptor activation (pK i = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.

Product References

Discovery of small molecule antagonists of TRPV1. - Discovery of small molecule antagonists of TRPV1.

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Conservation of functional and pharmacological properties in the distantly - Conservation of functional and pharmacological properties in the distantly

Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ. Mol Pharmacol. 2005 Aug;68(2):518-27. Epub 2005 May 23.

[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, - [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel,

Bianchi BR, El Kouhen R, Neelands TR, Lee CH, Gomtsyan A, Raja SN, Vaidyanathan SN, Surber B, McDonald HA, Surowy CS, Faltynek CR, Moreland RB, Jarvis MF, Puttfarcken PS. J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. Epub 2007 Jul 27.