SB 505124

• Supplier: Tocris Bioscience
• Catalog: 3265
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 694433-59-5
• Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
• Formula: C20H21N3O2
• Molecular Weight: 335.4
• Purity: >98 %
• Description: Selective inhibitor of transforming growth factor- β type I receptor (ALK5), ALK4 and ALK7 (IC 50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF- β and activin; does not inhibit other ALK family members.

Product References

SB-505124 is a selective inhibitor of transforming growth factor-beta type I - SB-505124 is a selective inhibitor of transforming growth factor-beta type I

DaCosta Byfield S, Major C, Laping NJ, Roberts AB. Mol Pharmacol. 2004 Mar;65(3):744-52.

Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced - Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced

Hu T, Ramachandrarao SP, Siva S, Valancius C, Zhu Y, Mahadev K, Toh I, Goldstein BJ, Woolkalis M, Sharma K. Am J Physiol Renal Physiol. 2005 Oct;289(4):F816-25.

The essential role of fibroblasts in esophageal squamous cell carcinoma-induced - The essential role of fibroblasts in esophageal squamous cell carcinoma-induced

Noma K, Smalley KS, Lioni M, Naomoto Y, Tanaka N, El-Deiry W, King AJ, Nakagawa H, Herlyn M. Gastroenterology. 2008 Jun;134(7):1981-93.