SB 525334

• Supplier: Tocris Bioscience
• Catalog: 3263
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 356559-20-1
• Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
• Formula: C21H21N5
• Molecular Weight: 343.42
• Purity: >97 %
• Description: Selective inhibitor of transforming growth factor- β receptor I (ALK5, TGF- β RI) (IC 50 = 14.3 nM). Inhibits TGF- β 1-induced smad2/3 nuclear localization and TGF- β RI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

Product References

Inhibition of gene markers of fibrosis with a novel inhibitor of transforming - Inhibition of gene markers of fibrosis with a novel inhibitor of transforming

Grygielko ET, Martin WM, Tweed C, Thornton P, Harling J, Brooks DP, Laping NJ. J Pharmacol Exp Ther. 2005 Jun;313(3):943-51. Epub 2005 Mar 15.

Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced - Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced

Higashiyama H, Yoshimoto D, Kaise T, Matsubara S, Fujiwara M, Kikkawa H, Asano S, Kinoshita M. Exp Mol Pathol. 2007 Aug;83(1):39-46. Epub 2006 Dec 24.

Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker - Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker

Laping NJ, Everitt JI, Frazier KS, Burgert M, Portis MJ, Cadacio C, Gold LI, Walker CL. Clin Cancer Res. 2007 May 15;13(10):3087-99.