SB 611812

• Supplier: Tocris Bioscience
• Catalog: 2650
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 345892-71-9
• Chemical Name: 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide
• Formula: C17H16Cl3F3N2O3S
• Molecular Weight: 491.74
• Purity: >99 %
• Description: Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.

Product References

Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in - Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in

Bousette N, Pottinger J, Ramli W, Ohlstein EH, Dhanak D, Douglas SA, Giaid A. Peptides. 2006 Nov;27(11):2919-26. Epub 2006 Aug 17.

Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat - Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat

Bousette N, Hu F, Ohlstein EH, Dhanak D, Douglas SA, Giaid A. J Mol Cell Cardiol. 2006 Aug;41(2):285-95. Epub 2006 Jun 22.

Urotensin-II and cardiovascular remodeling. - Urotensin-II and cardiovascular remodeling.

Papadopoulos P, Bousette N, Giaid A. Peptides. 2008 May;29(5):764-9. Epub 2007 Sep 29.