| Name | SB 612111 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4670 |
| Prices | $245.00, $1,005.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 371980-94-8 |
| Chemical Name | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride |
| Formula | C24H29Cl2NO.HCl |
| Molecular Weight | 454.86 |
| Purity | >97 % |
| Description | Selective NOP receptor antagonist (K i values are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ -, κ - and δ -receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model. |
| Supplier Page | Shop |
Zaratin PF, Petrone G, Sbacchi M, Garnier M, Fossati C, Petrillo P, Ronzoni S, Giardina GA, Scheideler MA. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61. Epub 2003 Oct 30.
Rizzi A, Gavioli EC, Marzola G, Spagnolo B, Zucchini S, Ciccocioppo R, Trapella C, Regoli D, Calo G. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74. Epub 2007 Feb 28.