| Name | SB 657510 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3573 |
| Prices | $195.00, $805.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 474960-44-6 |
| Chemical Name | 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide |
| Formula | C19H22BrClN2O5S |
| Molecular Weight | 505.81 |
| Purity | >98 % |
| Description | Selective urotensin-II (UT) receptor antagonist (K i values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca 2+ mobilization (IC 50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC 50 = 50 - 189 nM). |
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Douglas SA, Behm DJ, Aiyar NV, Naselsky D, Disa J, Brooks DP, Ohlstein EH, Gleason JG, Sarau HM, Foley JJ, Buckley PT, Schmidt DB, Wixted WE, Widdowson K, Riley G, Jin J, Gallagher TF, Schmidt SJ, Ridgers L, Christmann LT, Keenan RM, Knight SD, Dhanak D. Br J Pharmacol. 2005 Jul;145(5):620-35.
Behm DJ, McAtee JJ, Dodson JW, Neeb MJ, Fries HE, Evans CA, Hernandez RR, Hoffman KD, Harrison SM, Lai JM, Wu C, Aiyar NV, Ohlstein EH, Douglas SA. Br J Pharmacol. 2008 Oct;155(3):374-86.