SB 747651A dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5109
• Prices: $245.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1781882-72-1
• Chemical Name: 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanaminedihydrochloride
• Formula: C16H22N8O.2HCl
• Molecular Weight: 415.32
• Purity: >98 %
• Description: Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC 50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70 S6K activity in cells. Blocks IL-10 production in macrophages.

Product References

(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel - (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel

Bamford MJ, Alberti MJ, Bailey N, Davies S, Dean DK, Gaiba A, Garland S, Harling JD, Jung DK, Panchal TA, Parr CA, Steadman JG, Takle AK, Townsend JT, Wilson DM, Witherington J. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3402-6.

(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further - (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further

Bamford MJ, Bailey N, Davies S, Dean DK, Francis L, Panchal TA, Parr CA, Sehmi S, Steadman JG, Takle AK, Townsend JT, Wilson DM. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3407-11.

Characterization of the cellular action of the MSK inhibitor SB-747651A. - Characterization of the cellular action of the MSK inhibitor SB-747651A.

Naqvi S, Macdonald A, McCoy CE, Darragh J, Reith AD, Arthur JS. Biochem J. 2012 Jan 1;441(1):347-57.