SBE 13 hydrochloride

Name SBE 13 hydrochloride
Supplier Tocris Bioscience
Catalog 4118
Prices $99.00, $419.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1052532-15-6
Chemical Name N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanaminehydrochloride
Formula C24H27ClN2O4.HCl
Molecular Weight 479.4
Purity >99 %
Description Selective inhibitor of PLK1 (IC 50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G 0 /G 1 in primary cells.
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Product References

Freezing Polo in its sleep: targeting the inactive conformation of Polo-like - Freezing Polo in its sleep: targeting the inactive conformation of Polo-like

Eckerdt F. Cell Cycle. 2010 Mar 1;9(5):862. Epub 2010 Mar 1.

Biological impact of freezing Plk1 in its inactive conformation in cancer cells. - Biological impact of freezing Plk1 in its inactive conformation in cancer cells.

Keppner S, Proschak E, Kaufmann M, Strebhardt K, Schneider G, Spankuch B. Cell Cycle. 2010 Feb 15;9(4):761-73. Epub 2010 Feb 16.

SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors. - SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors.

Liu X. Cell Cycle. 2010 Feb 1;9(3):445-6. Epub 2010 Feb 1.