| Name | SC 144 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3810 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 917497-70-2 |
| Chemical Name | 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)2-pyrazinecarboxylicacidhydrazidehydrochloride |
| Formula | C16H11FN6O.HCl |
| Molecular Weight | 358.76 |
| Purity | >99 % |
| Description | Inhibitor of gp130 (IC 50 = 0.72 μ M); blocks cytokine-triggered gp130 signaling. Induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. Delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active. |
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