SC 51089

• Supplier: Tocris Bioscience
• Catalog: 4189
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 146033-02-5
• Chemical Name: 8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacid2-[1-oxo-3-(4-pyridinyl)propyl]hydrazidehydrochloride
• Formula: C22H19ClN4O3.HCl
• Molecular Weight: 459.33
• Purity: >99 %
• Description: Selective EP 1 prostanoid receptor antagonist (K i values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μ M for EP 1 , TP, EP 3 , EP 2 , EP 4 , FP and DP receptors respectively). Attenuates PGE 2 -induced neuronal cell death in vitro and slows tumor growth in vivo .

Product References

The utilization of recombinant prostanoid receptors to determine the affinities - The utilization of recombinant prostanoid receptors to determine the affinities

Abramovitz M, Adam M, Boie Y, Carriere M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.

Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery - Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery

Saleem S, Li RC, Wei G, Dore S. J Neurosci Res. 2007 Aug 15;85(11):2433-40.