SC 560

• Supplier: Tocris Bioscience
• Catalog: 3318
• Prices: $159.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 188817-13-2
• Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
• Formula: C17H12ClF3N2O
• Molecular Weight: 352.74
• Purity: >98 %
• Description: Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.009 and 6.3 μ M for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B 2 , gastric PGE 2 and dermal PDE 2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo . Orally active.

Product References

Pharmacological analysis of cyclooxygenase-1 in inflammation. - Pharmacological analysis of cyclooxygenase-1 in inflammation.

Smith CJ, Zhang Y, Koboldt CM, Muhammad J, Zweifel BS, Shaffer A, Talley JJ, Masferrer JL, Seibert K, Isakson PC. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13313-8.

Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian - Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian

Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK. Cancer Res. 2005 May 1;65(9):3735-44.

COX inhibition and NSAID-induced gastric damage--roles in various pathogenic - COX inhibition and NSAID-induced gastric damage--roles in various pathogenic

Takeuchi K, Tanaka A, Hayashi Y, Yokota A. Curr Top Med Chem. 2005;5(5):475-86.