| Name | SC 57461A |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1550 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 423169-68-0 |
| Chemical Name | N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochloride |
| Formula | C20H25NO3.HCl |
| Molecular Weight | 363.88 |
| Purity | >98 % |
| Description | Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active. |
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Askonas LJ, Kachur JF, Villani-Price D, Liang CD, Russell MA, Smith WG. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82.
Kachur JF, Askonas LJ, Villani-Price D, Ghoreishi-Haack N, Won-Kim S, Liang CD, Russell MA, Smith WG. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7.
Penning TD, Russell MA, Chen BB, Chen HY, Liang CD, Mahoney MW, Malecha JW, Miyashiro JM, Yu SS, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG. J Med Chem. 2002 Aug 1;45(16):3482-90.