SC 58125

• Supplier: Tocris Bioscience
• Catalog: 3107
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 162054-19-5
• Chemical Name: 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
• Formula: C17H12F4N2O2S
• Molecular Weight: 384.35
• Purity: >98 %
• Description: Selective cyclooxygenase 2 (COX-2) inhibitor (IC 50 values are 0.04 and >100 μ M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.

Product References

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) - A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2)

Gierse JK, McDonald JJ, Hauser SD, Rangwala SH, Koboldt CM, Seibert K. J Biol Chem. 1996 Jun 28;271(26):15810-4.

A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon - A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon

Williams CS, Sheng H, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG, DuBois RN. Neoplasia. 2001 Sep-Oct;3(5):428-36.