SC 236

• Supplier: Tocris Bioscience
• Catalog: 2895
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 170569-86-5
• Chemical Name: 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• Formula: C16H11ClF3N3O2S
• Molecular Weight: 401.79
• Purity: >99 %
• Description: Selective COX-2 inhibitor (IC 50 values are 0.005 and 17.8 μ M for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

Product References

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) - A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2)

Gierse JK, McDonald JJ, Hauser SD, Rangwala SH, Koboldt CM, Seibert K. J Biol Chem. 1996 Jun 28;271(26):15810-4.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of - Synthesis and biological evaluation of the 1,5-diarylpyrazole class of

Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. J Med Chem. 1997 Apr 25;40(9):1347-65.

Antimetastatic activity of a cyclooxygenase-2 inhibitor. - Antimetastatic activity of a cyclooxygenase-2 inhibitor.

Roche-Nagle G, Connolly EM, Eng M, Bouchier-Hayes DJ, Harmey JH. Br J Cancer. 2004 Jul 19;91(2):359-65.