SCH 221510

• Supplier: Tocris Bioscience
• Catalog: 1400
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 322473-89-2
• Chemical Name: 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
• Formula: C28H31NO
• Molecular Weight: 397.55
• Purity: >99 %
• Description: Potent and selective nociceptin opioid receptor (NOP) agonist (EC 50 values are 12, 693, 683 and 8071 nM, and K i values are 0.3, 65, 131 and 2854 nM at NOP, μ -, κ - and δ -opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo . Orally active.

Product References

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. - The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential.

Lambert DG. Nat Rev Drug Discov. 2008 Aug;7(8):694-710.

The anxiolytic-like effects of the novel, orally active nociceptin opioid - The anxiolytic-like effects of the novel, orally active nociceptin opioid

Varty GB, Lu SX, Morgan CA, Cohen-Williams ME, Hodgson RA, Smith-Torhan A, Zhang H, Fawzi AB, Graziano MP, Ho GD, Matasi J, Tulshian D, Coffin VL, Carey GJ. J Pharmacol Exp Ther. 2008 Aug;326(2):672-82.

Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin - Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin

Yang SW, Ho G, Tulshian D, Greenlee WJ, Tan Z, Zhang H, Smith-Torhan A, Fawzi A, Anthes J, Lu S, Varty G, Fernandez X, McLeod RL, Hey J. Bioorg Med Chem Lett. 2009 May 1;19(9):2482-6.