SCH 28080

Name SCH 28080
Supplier Tocris Bioscience
Catalog 0925
Prices $185.00, $755.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 76081-98-6
Chemical Name 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Formula C17H15N3O
Molecular Weight 277.33
Purity >99 %
Description Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .
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Product References

Gastric antisecretory and cytoprotective activities of SCH 28080. - Gastric antisecretory and cytoprotective activities of SCH 28080.

Long JF, Chiu PJ, Derelanko MJ, Steinberg M. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.

Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase - Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase

Scott CK, Sundell E, Castrovilly L. Biochem Pharmacol. 1987 Jan 1;36(1):97-104.

SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the - SCH28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the

Vagin O, Denevich S, Munson K, Sachs G. Biochemistry. 2002 Oct 22;41(42):12755-62.