SCH 50911

• Supplier: Tocris Bioscience
• Catalog: 2463
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 733717-87-8
• Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholineaceticacid
• Formula: C8H15NO3
• Molecular Weight: 173.21
• Purity: >98 %
• Description: A selective, competitive and orally active GABA B antagonist. Displays an IC 50 of 1.1 μ M at GABA B , approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABA A at concentrations up to 100 μ M.

Product References

The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor - The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor

Bolser DC, Blythin DJ, Chapman RW, Egan RW, Hey JA, Rizzo C, Kuo SC, Kreutner W. J Pharmacol Exp Ther. 1995 Sep;274(3):1393-8.

Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor - Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor

Hosford DA, Wang Y, Liu CC, Snead OC 3rd. J Pharmacol Exp Ther. 1995 Sep;274(3):1399-403.

The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor - The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor

Ong J, Marino V, Parker DA, Kerr DI, Blythin DJ. Eur J Pharmacol. 1998 Nov 27;362(1):35-41.