SCH 51344

• Supplier: Tocris Bioscience
• Catalog: 0984
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 171927-40-5
• Chemical Name: 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
• Formula: C16H20N4O3
• Molecular Weight: 316.35
• Purity: >99 %
• Description: Potent MTH1 inhibitor (K d = 49 nM). Inhibits Ras-induced malignant transformation and increases α -actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.

Product References

SCH 51344-induced reversal of RAS-transformation is accompanied by the specific - SCH 51344-induced reversal of RAS-transformation is accompanied by the specific

Walsh AB, Dhanasekaran M, Bar-Sagi D, Kumar CC. Oncogene. 1997 Nov 20;15(21):2553-60.

SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway. - SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway.

Kumar CC, Ohashi K, Nagata K, Walsh A, Bar-Sagi D, Mizuno K. Ann N Y Acad Sci. 1999;886:122-31.

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. - Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Gokturk C, Sanjiv K, Stromberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Nature. 2014 Apr 10;508(7495):222-7.