SCH 529074

Name SCH 529074
Supplier Tocris Bioscience
Catalog 5280
Prices $195.00, $805.00
Sizes 10 mg, 50 mg
Cas Number 922150-11-6
Chemical Name N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
Formula C31H36Cl2N6
Molecular Weight 563.56
Purity >98 %
Description Restores mutant p53 activity. Binds p53 DNA binding domain (K d = 1-2 μ M) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.
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Product References

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding - SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding

Demma M, Maxwell E, Ramos R, Liang L, Li C, Hesk D, Rossman R, Mallams A, Doll R, Liu M, Seidel-Dugan C, Bishop WR, Dasmahapatra B. J Biol Chem. 2010 Apr 2;285(14):10198-212.

Translational approaches targeting the p53 pathway for anti-cancer therapy. - Translational approaches targeting the p53 pathway for anti-cancer therapy.

Essmann F, Schulze-Osthoff K. Br J Pharmacol. 2012 Jan;165(2):328-44.