SCH 79797 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2270
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1216720-69-2
• Chemical Name: N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diaminedihydrochloride
• Formula: C23H25N5.2HCl
• Molecular Weight: 444.41
• Purity: >99 %
• Description: Potent, selective non-peptide PAR 1 receptor antagonist (IC 50 = 70 nM). Inhibits haTRAP-induced- but not γ -thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR 1 agonist- or thrombin-induced increases in cytosolic Ca 2+ in vascular smooth muscle cells.

Product References

Structure-activity relationships of pyrroloquinazolines as thrombin receptor - Structure-activity relationships of pyrroloquinazolines as thrombin receptor

Ahn HS, Arik L, Boykow G, Burnett DA, Caplen MA, Czarniecki M, Domalski MS, Foster C, Manna M, Stamford AW, Wu Y. Bioorg Med Chem Lett. 1999 Jul 19;9(14):2073-8.

Inhibition of cellular action of thrombin by - Inhibition of cellular action of thrombin by

Ahn HS, Foster C, Boykow G, Stamford A, Manna M, Graziano M. Biochem Pharmacol. 2000 Nov 15;60(10):1425-34.

A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated - A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated

Lidington EA, Steinberg R, Kinderlerer AR, Landis RC, Ohba M, Samarel A, Haskard DO, Mason JC. Am J Physiol Cell Physiol. 2005 Dec;289(6):C1437-47. Epub 2005 Aug 3.