SCIO 469 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1592
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 309913-83-5
• Chemical Name: 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamidehydrochloride
• Formula: C27H30ClFN4O3.HCl
• Molecular Weight: 549.46
• Purity: >98 %
• Description: Selective, ATP-competitive p38 inhibitor (IC 50 = 9 nM for p38 α in vitro ). Displays approximately 10-fold selectivity for p38 α over p38 β and 2000-fold selectivity for p38 α over 20 other kinases. Reduces p38 α phosphorylation in multiple myeloma cells in vitro and in vivo ; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells.

Product References

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against - p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against

Hideshima T, Podar K, Chauhan D, Ishitsuka K, Mitsiades C, Tai YT, Hamasaki M, Raje N, Hideshima H, Schreiner G, Nguyen AN, Navas T, Munshi NC, Richardson PG, Higgins LS, Anderson KC. Oncogene. 2004 Nov 18;23(54):8766-76.

Role of the p38 mitogen-activated protein kinase pathway in the generation of - Role of the p38 mitogen-activated protein kinase pathway in the generation of

Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, Davis RJ, Platanias LC. Cancer Res. 2006 Jul 1;66(13):6763-71.

Inhibition of p38alpha mitogen-activated protein kinase prevents the development - Inhibition of p38alpha mitogen-activated protein kinase prevents the development

Vanderkerken K, Medicherla S, Coulton L, De Raeve H, Willems A, Lawson M, Van Camp B, Protter AA, Higgins LS, Menu E, Croucher PI. Cancer Res. 2007 May 15;67(10):4572-7. Epub 2007 May 10.